Vitamin B6 Effects on Breast Pain in Women of Reproductive Age: A Systematic Review

Context: Vitamin B6, which is known as pyridoxine, used a nutritional supplement for many therapeutic purposes in medical centers. Women's health important because they are assumed the guarantors of societies. Breast pain common complaint women reproductive age and one most reasons women’s referral to The present study reviewed impact vitamin B6 on breast pain. Evidence Acquisition: In order gather relevant articles, databases IRCT, Iran Doc, SID, MagIran, Medline, Cochrane, Embase, PubMed, Scopus, Science Direct, Web Knowledge were searched from 1980 up July 2019. Keywords extracted MeSH, included "Pyridoxol", "Rodex”, "PLP", "Pyridoxal-5-Phosphate", "Pyridoxine Hydrochloride", "Pyridoxine", "Vitamin B6", "Mastodynia", "Mammalgia", "Breast Pain", (Pain AND Breast), "Mastalgia", "Cycle Mastalgia", "Non-Cycle Mastalgia". same keywords also Persian databases. All selected studies had control intervention groups compared pain-relieving effects with that other therapies or placebo. Results: Among 338 examined seven fulfilled our inclusion criteria review. results showed was more effective than placebo improving even at low doses. Conclusions: relieving However, there supplements medications treat pain, so some factors like cost-effectiveness, availability, side should be considered choose suitable agent.